Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-753 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4620 Imported from RMgmDB
P. falciparum 3D7
Possible
25843709 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
22698672
\"In the pfsdha disruptants, Fp mRNA and polypeptides were decreased, and neither SQR nor SDH activity of complex II was detected. The suppression of complex II caused growth retardation of the intraerythrocytic forms, suggesting that complex II contributes to intraerythrocytic parasite growth, although it is not essential for survival. The growth retardation in the pfsdha disruptant was rescued by the addition of succinate, but not by fumarate. This indicates that complex II functions as a quinol-fumarate reductase (QFR) to form succinate from fumarate in the intraerythrocytic parasite.\"
Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-753 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-4620 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-753
Normal numbers of gametocytes are produced and male gamete formation (exflagellation) was normal. The conversion rate of female gametes to ookinetes in vitro of Pbsdha(-) was significantly reduced to 17% of wild type parasites.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-753
The conversion rate of female gametes to ookinetes in vitro of Pbsdha(-) was significantly reduced to 17% of wild type parasites.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-753
The conversion rate of female gametes to ookinetes in vitro of Pbsdha(-) was significantly reduced to 17% of wild type parasites.No oocysts are formed.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4620
No formation of oocysts
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4620
No formation of oocysts; no formation of salivary gland sporozoites
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4620
See Additional Information: Evidence for a role during liver stage development
Imported from RMgmDB
P. falciparum 3D7 Asexual
No difference
25843709 Theo Sanderson, Wellcome Trust Sanger Institute

More information

PlasmoDB PBANKA_0518200
GeneDB PBANKA_0518200
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB001099.03.0, PB001230.02.0, PB300675.00.0, PB300700.00.0, PBANKA_051820
Orthologs PCHAS_0518300 , PF3D7_1034400 , PKNH_0619600 , PVP01_0619500 , PVX_111005 , PY17X_0519300
Google Scholar Search for all mentions of this gene