Last updated 3 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. yoelii yoelii 17X
Possible
RMgm-4756 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Refractory
RMgm-4346 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-5196 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
No difference
RMgm-4756 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
Difference from wild-type
RMgm-4756
normal production of female gametocytes; normal exflagellation
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-5196 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-5196
Normal (wild type) numbers of gametocytes are produced; male gamete formation ~2fold reduced (as determined by counting exflagellation); female gamete formation reduced by ~ 30%. Crossing experiments indicate a more severe defect in female gametes compared to males.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-5196
Reduced ookinete formation (Whereas >93% of wild-type zygotes were transformed into mature ookinetes after 24 h of culture, pbgpr180 parasites had a ~50% conversion rate.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-5196
~50% reduction in the percentage of infected mosquitoes and ~80% decrease in oocyst density.
Imported from RMgmDB

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