PY17X_0927200 calcium-dependent protein kinase 7 (CDPK7)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Refractory |
RMgm-537 | Imported from RMgmDB | |
| P. berghei ANKA |
Refractory |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
24895132 Partial stalling at ring -> troph transition |
Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
Attenuated |
24895132 Partial stalling at ring -> troph transition |
Theo Sanderson, Wellcome Trust Sanger Institute |
Imaging data (from Malaria Metabolic Pathways)
CDPK7 may be present in the ER and vesicles. A IFA was performed to localize CDPK7 in various asexual stages of the parasite using antisera against CDPK7. R, rings; T, trophozoites; S, schizonts. B. Co-staining was done using antisera against CDPK7 and BiP on trophozoites (a) or with anti-RAP1 mAb on free merozoites (b). C. Immuno-EM performed on a trophozoite stage parasite indicated the presence of CDPK7 in ER and vesicular compartments (arrows). Various parasite organelles are indicated: FV, food vacuole; PM/PVM, parasite membrane/parasite vacuolar membrane; ER, Endoplasmic Reticulum; N, Nucleus.Kumar P, Tripathi A, Ranjan R, Halbert J, Gilberger T, Doerig C, Sharma P. Regulation of Plasmodium falciparum development by Calcium-Dependent Protein Kinase 7 (PfCDPK7). J Biol Chem. 2014 Jun 3. [Epub ahead of print]
See original on MMPMore information
| PlasmoDB | PY17X_0927200 |
| GeneDB | PY17X_0927200 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | null |
| Orthologs | PBANKA_0925200 , PCHAS_0919200 , PF3D7_1123100 , PKNH_0920900 , PVP01_0923700 , PVX_091770 |
| Google Scholar | Search for all mentions of this gene |