PVP01_1217800 tryptophan--tRNA ligase, putative (cTrpRS)

Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory		 PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory		 USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

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Imaging data (from Malaria Metabolic Pathways)

P. falciparum encodes cytosolic and apicoplast tryptophanyl-tRNA synthetase isoforms. The first panel shows live cell fluorescence microscopy of TrpRSapi-GFP and live mitochondrial staining, while the second and third panels show IFAs of P. falciparum TrpRSapi-GFP and TrpRScyt-GFP in relation to the apicoplast marker ACP. Schematic representations of transfected plasmids are indicated above each panel. ACP, acyl-carrier protein; DIC, differential interference contrast.Pasaje CF, Cheung V, Kennedy K, Lim EE, Baell JB, Griffin MD, Ralph SA. Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum. Sci Rep. 2016 6:27531.

See original on MMP

More information

PlasmoDB PVP01_1217800
GeneDB PVP01_1217800
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) null
Orthologs PBANKA_1350700 , PCHAS_1355300 , PF3D7_1336900 , PKNH_1264400 , PVX_082775 , PY17X_1355800
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