PF3D7_1336900 tryptophan--tRNA ligase (cTrpRS)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. berghei ANKA |
Refractory |
PlasmoGEM (Barseq) | PlasmoGEM | |
Mutant phenotypes [+]
None reported yet. Please press the '+' button above to add one.Imaging data (from Malaria Metabolic Pathways)
P. falciparum encodes cytosolic and apicoplast tryptophanyl-tRNA synthetase isoforms. The first panel shows live cell fluorescence microscopy of TrpRSapi-GFP and live mitochondrial staining, while the second and third panels show IFAs of P. falciparum TrpRSapi-GFP and TrpRScyt-GFP in relation to the apicoplast marker ACP. Schematic representations of transfected plasmids are indicated above each panel. ACP, acyl-carrier protein; DIC, differential interference contrast.Pasaje CF, Cheung V, Kennedy K, Lim EE, Baell JB, Griffin MD, Ralph SA. Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum. Sci Rep. 2016 6:27531.
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| PlasmoDB | PF3D7_1336900 |
| GeneDB | PF3D7_1336900 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PF13_0205 |
| Orthologs | PBANKA_1350700 , PCHAS_1355300 , PKNH_1264400 , PVP01_1217800 , PVX_082775 , PY17X_1355800 |
| Google Scholar | Search for all mentions of this gene |