PVP01_1214900 ABC transporter B family member 5, putative (ABCB5)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-1169 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
RMgm-1168 | Imported from RMgmDB | |
| P. berghei ANKA |
Refractory |
RMgm-193 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
26991313 | Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. yoelii yoelii 17X |
Possible |
RMgm-4777 | Imported from RMgmDB | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
Difference from wild-type |
RMgm-1169
A reduced growth rate of asexual blood stages (mean multiplication rate of 6.8x per 24 hour in the cloning assay; wild type parasites show a multiplication rate of 10x per 24 hour in this assay) |
Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Difference from wild-type |
RMgm-1168
A reduced growth rate of asexual blood stages (mean multiplication rate of 6.8x per 24 hour in the cloning assay; wild type parasites show a multiplication rate of 10x per 24 hour in this assay) |
Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. yoelii yoelii 17X | Asexual |
No difference |
RMgm-4777 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-1169 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-1168 | Imported from RMgmDB |
| P. yoelii yoelii 17X | Gametocyte |
Difference from wild-type |
RMgm-4777
reduced production of male gametocytes; (somewhat) reduced exflagellation |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
No difference |
RMgm-1169 | Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
No difference |
RMgm-1168 | Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-1169
Reduced numbers of (mature) oocysts |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-1168
Reduced numbers of (mature) oocysts |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-1169
Reduced numbers of (mature) oocysts.Stronly reduced numbers (>10 times) of salivary gland sporozoites |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-1168
Reduced numbers of (mature) oocysts.Stronly reduced numbers (>10 times) of salivary gland sporozoites |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-1169
Strongly reduced numbers (>10 times) of salivary gland sporozoites. However, sporozoites show normal infectivity to mice. Intravenous injection of 10.000 mutant sporozoites resulted in blood infections in mice (n=3) with a prepatent period (5-6 days) that is comparable to the prepatent period of wild type parasites. |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-1168
Strongly reduced numbers (>10 times) of salivary gland sporozoites. However, sporozoites show normal infectivity to mice. Intravenous injection of 10.000 mutant sporozoites resulted in blood infections in mice (n=3) with a prepatent period (5-6 days) that is comparable to the prepatent period of wild type parasites. |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
Localization of PfMRP2 and PfMDR5 within the asexual stages of P. falciparum. In column 1 blue (DAPI) shows the nuclear staining. In column 2 red shows PfMRP2 staining. In column 3 green shows glycophorin-A (A and B) or PfERC (C and D) staining. Column 4 shows the merge of column 1–3. Finally, column 5 shows the differential interference contrast image. Represented in rows: A, multiple infected erythrocyte: rings; B, double infected erythrocyte: trophozoites; C, three trophs (T) and two rings (R); D, early schizont. Arrow indicates food vacuole. Both transporters are localized to the plasma membrane in all asexual stages of the parasite.Kavishe RA, van den Heuvel JJ, van de Vegte-Bolmer M, Luty AJ, Russel FG, Koenderink JB. Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane. Malar J. 2009 8:205.
See original on MMPMore information
| PlasmoDB | PVP01_1214900 |
| GeneDB | PVP01_1214900 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | null |
| Orthologs | PBANKA_1353300 , PCHAS_1357900 , PF3D7_1339900 , PKNH_1261500 , PVX_082915 , PY17X_1358700 |
| Google Scholar | Search for all mentions of this gene |