Last updated 7 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
18452584 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
RMgm-1374 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-307 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-169 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. yoelii yoelii 17X
Possible
RMgm-4509 Imported from RMgmDB
P. yoelii yoelii 17X
Possible
RMgm-4795 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Gametocyte
No difference
18452584 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Asexual
No difference
RMgm-1374 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-307 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-169 Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. yoelii yoelii 17X Asexual
No difference
RMgm-4795 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-1374 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-307 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-169 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
Difference from wild-type
RMgm-4795
(somewhat) reduced production of gametocytes; normal exflagellation
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-307
Normal fertilisation rates and ookinete production. Ookinetes had a strongly reduced capacity to develop into oocysts (an oocyst production in Anopheles stephensi of only 2.2% of wild type oocysts). Mutant ookinetes had a greatly reduced gliding motility (speed).
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-169
Normal fertilisation rates and ookinete production. Ookinetes are not able to penetrate the cells of the midgut wall. The motility of ookinetes was reduced. The moving velocity of mutant parasites was much slower than that of wild type (wild type = 5.7 1.4 m/min, mutant = 0.6 0.1m/min)
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-307
Ookinetes had a strongly reduced capacity to develop into oocysts (an oocyst production in Anopheles stephensi of only 2.2% of wild type oocysts). Mutant ookinetes had a greatly reduced gliding motility (speed).
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-169
No oocyst formation.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1374
No sporozoites in vivo
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1374
No transmission by bite of infected mosquitoes
Imported from RMgmDB

More information

PlasmoDB PF3D7_1360500
GeneDB PF3D7_1360500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL13P1.301, PF13_0320
Orthologs PBANKA_1136700 , PCHAS_1136200 , PKNH_1110800 , PVP01_1111400 , PVX_114990 , PY17X_1138200
Google Scholar Search for all mentions of this gene