Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
37819580 (Knock down)
\"Parasites lacking PfOPA3 show severe defects in the development of functional mitochondria; the mitochondria showed reduced activity of mtETC but not ATP synthesis, as evidenced by reduced activity of complex III of the mtETC, and increased sensitivity for drugs targeting DHODH as well as complex III, but not to the drugs targeting complex V. Further, PfOPA3 downregulation leads to reduction in the level of mitochondrial proton transport uncoupling protein (PfUCP) to compensate reduced activity of complex III and maintain proton efflux across the inner membrane. The reduced activity of DHODH, which is responsible for pyrimidine biosynthesis required for nuclear DNA synthesis, resulted in a significant reduction in parasite nuclear division and generation of progeny.\"
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PCHAS_1326200
GeneDB PCHAS_1326200
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC301570.00.0, PCAS_132620, PCHAS_132620
Orthologs PBANKA_1322900 , PF3D7_1459300 , PKNH_1222500 , PVP01_1247600 , PVX_117495 , PY17X_1326700
Google Scholar Search for all mentions of this gene