Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-96 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-96 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-96 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-96
Normal production of ookinetes. Reduced ookinete invasion and traversal of the midgut wall (see also 'Additional remarks phenotype').
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-96
Strong reduction of oocyst formation (0% of wild type). Only two oocysts were observed in a total of 130 mosquitoes.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-96
No sporozoites are produced. No tramission to C57BL/6 mice by mosquito bite.When ookinetes were injected directly into the mosquito hemocoel to bypass the midgut barrier mosquito infectivity was rescued as assayed by the quantification of salivary gland sporozoites. The development of oocysts in the hemocoel is thus not affected. The formed sporozoites were also fully infectious to mice by mosquito-bite.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-96
When ookinetes were injected directly into the mosquito hemocoel to bypass the midgut barrier mosquito infectivity was rescued as assayed by the quantification of salivary gland sporozoites. The development of oocysts in the hemocoel is thus not affected. The formed sporozoites were also fully infectious to mice by mosquito-bite.
Imported from RMgmDB

More information

PlasmoDB PBANKA_1353400
GeneDB PBANKA_1353400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000652.03.0, PB300002.00.0, PBANKA_135340
Orthologs PCHAS_1358000 , PF3D7_1340000 , PKNH_1261400 , PVP01_1214800 , PVX_082920 , PY17X_1358800
Google Scholar Search for all mentions of this gene