| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-532 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
RMgm-482 | Imported from RMgmDB | |
| P. falciparum 3D7 |
Possible |
22127061 | Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-532 | Imported from RMgmDB |
| P. berghei ANKA | Asexual |
No difference |
RMgm-482 | Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-532 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-482 | Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-532
Ookinete numbers (in vitro) reduced to 52% of wild type |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
No difference |
RMgm-482 | Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-532
Oocyst numbers (day 12-14) reduced to 20% of wild type |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
No difference |
RMgm-482 | Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
No difference |
RMgm-532 | Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-482
Normal numbers of salivary gland sporozoites are produced. Sporozoites showed reduced gliding motility and cell traversal capacity in vitro. Invasion of HepG2 cells in vitro was comparable to that of wild type parasites. Infectivity of sporozoites to mice was strongly reduced (as tested by intravenous injection of purified sporozoites or after infection of mice by mosquito bite). Salivary gland sporozoites show premature development into early liver stage forms (see further 'Additional remarks phenotype') |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-532
transmitted by mosquito bite |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-482
Sporozoites showed reduced gliding motility and cell traversal capacity in vitro. Invasion of HepG2 cells in vitro was comparable to that of wild type parasites. Infectivity of sporozoites to mice was strongly reduced (as tested by intravenous injection of purified sporozoites or after infection of mice by mosquito bite). Salivary gland sporozoites show premature development into early liver stage forms (see further 'Additional remarks phenotype') |
Imported from RMgmDB |
| PlasmoDB | PBANKA_0205800 |
| GeneDB | PBANKA_0205800 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PB001255.02.0, PB102277.00.0, PB105212.00.0, PB108190.00.0, PBANKA_020580 |
| Orthologs | PCHAS_0204200 , PF3D7_0107600 , PY17X_0207200 |
| Google Scholar | Search for all mentions of this gene |