Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
27849032 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7 Asexual
No difference
27849032 Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

Subcellular localization of PfGMD and PfFS expressed in P. falciparum. PfGMD-HA-expressing and PfFS-HA-expressing trophozoites were labelled with anti-HA (green), anti-PfHSP70 (red) and DAPI for nuclear staining (blue). First column represents the differential interference contrast (DIC) and last column the merge of HA and PfHSP70 signals. Similar co-localization was observed in other stages of the intraerythrocytic life cycle (not shown). Sanz S, Bandini G, Ospina D, Bernabeu M, Mariño K, Fernández-Becerra C, Izquierdo L. Biosynthesis of GDP-fucose and other sugar nucleotides in the blood-stages of Plasmodium falciparum. J Biol Chem. 2013288(23):16506-17

See original on MMP

Subcellular localization of PfGMD and PfFS expressed in P. falciparum. PfGMD-HA-expressing and PfFS-HA-expressing trophozoites were labelled with anti-HA (green), anti-PfHSP70 (red) and DAPI for nuclear staining (blue). First column represents the differential interference contrast (DIC) and last column the merge of HA and PfHSP70signals. Similar co-localization was observed in other stages of the intraerythrocytic life cycle (not shown).Sanz S, Bandini G, Ospina D, Bernabeu M, Mariño K, Fernández-Becerra C, Izquierdo L. Biosynthesis of GDP-fucose and other sugar nucleotides in the blood-stages of Plasmodium falciparum. J Biol Chem. 2013 Apr 24. [Epub ahead ofprint] PMID:

See original on MMP

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