PKNH_1426500 GDP-mannose 4,6-dehydratase, putative (GMD)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
27849032 | Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. falciparum 3D7 | Asexual |
No difference |
27849032 | Theo Sanderson, Wellcome Trust Sanger Institute |
Imaging data (from Malaria Metabolic Pathways)
Subcellular localization of PfGMD and PfFS expressed in P. falciparum. PfGMD-HA-expressing and PfFS-HA-expressing trophozoites were labelled with anti-HA (green), anti-PfHSP70 (red) and DAPI for nuclear staining (blue). First column represents the differential interference contrast (DIC) and last column the merge of HA and PfHSP70 signals. Similar co-localization was observed in other stages of the intraerythrocytic life cycle (not shown). Sanz S, Bandini G, Ospina D, Bernabeu M, Mariño K, Fernández-Becerra C, Izquierdo L. Biosynthesis of GDP-fucose and other sugar nucleotides in the blood-stages of Plasmodium falciparum. J Biol Chem. 2013288(23):16506-17
See original on MMP
Subcellular localization of PfGMD and PfFS expressed in P. falciparum. PfGMD-HA-expressing and PfFS-HA-expressing trophozoites were labelled with anti-HA (green), anti-PfHSP70 (red) and DAPI for nuclear staining (blue). First column represents the differential interference contrast (DIC) and last column the merge of HA and PfHSP70signals. Similar co-localization was observed in other stages of the intraerythrocytic life cycle (not shown).Sanz S, Bandini G, Ospina D, Bernabeu M, Mariño K, Fernández-Becerra C, Izquierdo L. Biosynthesis of GDP-fucose and other sugar nucleotides in the blood-stages of Plasmodium falciparum. J Biol Chem. 2013 Apr 24. [Epub ahead ofprint] PMID:
See original on MMPMore information
| PlasmoDB | PKNH_1426500 |
| GeneDB | PKNH_1426500 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PK8_1330w, PKH_142460 |
| Orthologs | PBANKA_1423700 , PCHAS_1425500 , PF3D7_0813800 , PVP01_1426500 , PVX_123080 , PY17X_1425700 |
| Google Scholar | Search for all mentions of this gene |