Disruptability [+]

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Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
29582546 (Knock down)
glmS knockdown gave 90% reduction of parasitaemia after two cycles. No merozoites formed in 50% of schizonts, despite normal nuclear division. Parasites could not recover if knockdown was removed after the onset of schizogony. Trafficking was severely disrupted (see details in paper).
Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

The putative protein sorting receptor PfSortilin localizes to the P. falciparum Golgi apparatus. Co-localization of PfSortilin-HA and ERD2 in aldehyde-fixed clone C9 parasites. T, trophozoite; Sz, schizont. Scale bar, 2 mm. In trophozoite- and schizont-stage parasites, PfSortilin-HA localized to puncta that were also recognized by antibodies to the Golgi marker ERD2 (Fig. 4C). In ring-stage parasites, PfSortilin-HA could not be detected above non-specific background, even though the Golgi apparatus was present as determined by ERD2 immunolocalization.Krai P, Dalal S, Klemba M. Evidence for a Golgi-to-Endosome Protein Sorting Pathway in Plasmodium falciparum. PLoS One. 2014 9(2):e89771. PMID:

See original on MMP

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