Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
31413195 (Conditional)
'Deletion of the PfPATPL1 gene inhibits secretion of PfPLP2, reducing the efficiency of gamete egress. Deletion of PfPATPL1 also reduces the efficiency of oocyst formation in mosquitoes. '
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
Egress defect
31413195 (Conditional)
'Deletion of the PfPATPL1 gene inhibits secretion of PfPLP2, reducing the efficiency of gamete egress. Deletion of PfPATPL1 also reduces the efficiency of oocyst formation in mosquitoes. '
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
Attenuated
31413195 (Conditional)
Conditional deletion of the gene encoding PfPATPL1 does not affect asexual growth of blood-stage parasites or the formation of gametocytes. However, loss of PfPATPL1 results in reduced efficiency of rounding up, gamete egress, and exflagellation. Moreover, we demonstrate that PfPATPL1 plays a role in translocation of PfPLP2 to the periphery of gametes to enable egress. Importantly, loss of PfPATPL1 in gametocytes reduces transmission efficiency in mosquitos, identifying PfPATPL1 as a player in the process of gametogenesis and a potential target for development of drugs to block malaria transmission.
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Oocyst
Attenuated
31413195 (Conditional)
'Deletion of the PfPATPL1 gene inhibits secretion of PfPLP2, reducing the efficiency of gamete egress. Deletion of PfPATPL1 also reduces the efficiency of oocyst formation in mosquitoes. '
Theo Sanderson, Francis Crick Institute

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