| Species | Disruptability | Reference | Submitter |
|---|---|---|---|
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen |
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
No difference |
31413195 (Conditional)
'Deletion of the PfPATPL1 gene inhibits secretion of PfPLP2, reducing the efficiency of gamete egress. Deletion of PfPATPL1 also reduces the efficiency of oocyst formation in mosquitoes. ' |
Theo Sanderson, Francis Crick Institute |
| P. falciparum 3D7 | Gametocyte |
Egress defect |
31413195 (Conditional)
'Deletion of the PfPATPL1 gene inhibits secretion of PfPLP2, reducing the efficiency of gamete egress. Deletion of PfPATPL1 also reduces the efficiency of oocyst formation in mosquitoes. ' |
Theo Sanderson, Francis Crick Institute |
| P. falciparum 3D7 | Gametocyte |
Attenuated |
31413195 (Conditional)
Conditional deletion of the gene encoding PfPATPL1 does not affect asexual growth of blood-stage parasites or the formation of gametocytes. However, loss of PfPATPL1 results in reduced efficiency of rounding up, gamete egress, and exflagellation. Moreover, we demonstrate that PfPATPL1 plays a role in translocation of PfPLP2 to the periphery of gametes to enable egress. Importantly, loss of PfPATPL1 in gametocytes reduces transmission efficiency in mosquitos, identifying PfPATPL1 as a player in the process of gametogenesis and a potential target for development of drugs to block malaria transmission. |
Theo Sanderson, Francis Crick Institute |
| P. falciparum 3D7 | Oocyst |
Attenuated |
31413195 (Conditional)
'Deletion of the PfPATPL1 gene inhibits secretion of PfPLP2, reducing the efficiency of gamete egress. Deletion of PfPATPL1 also reduces the efficiency of oocyst formation in mosquitoes. ' |
Theo Sanderson, Francis Crick Institute |
| PlasmoDB | PF3D7_0209100 |
| GeneDB | PF3D7_0209100 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PF02_0087, PFB0410c |
| Orthologs | PBANKA_0306200 , PCHAS_0308400 , PKNH_0412000 , PVP01_0415700 , PVX_003910 , PY17X_0306800 |
| Google Scholar | Search for all mentions of this gene |