Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1369 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4342 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Refractory
35404116
Eight KO attempts failed
Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-1369
Reduced parasite multiplication rate (PMR): 55%
Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
Difference from wild-type
RMgm-4342
Not essential for blood stage growth/multiplication
Imported from RMgmDB
P. falciparum 3D7 Asexual
No difference
35404116 (Knock down)
No difference noted with partial knockdown
Theo Sanderson, Francis Crick Institute
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-1369
Strongly reduced exflagellation
Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-1369 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1369
No transmission by bite of infected mosquitoes; except an occasional breakthrough infection, normal liver-stage parasite numbers and size in vitro but with distorted nuclei
Imported from RMgmDB

More information

PlasmoDB PKNH_1241500
GeneDB PKNH_1241500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK14_1805w, PKH_126550
Orthologs PBANKA_1304700 , PCHAS_1307900 , PF3D7_1440800 , PVP01_1266200 , PVX_118450 , PY17X_1308500
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