Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. yoelii yoelii 17X
Possible
RMgm-5289 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. yoelii yoelii 17X Asexual
No difference
RMgm-5289 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-5289 Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
Difference from wild-type
RMgm-5289
The aprp4 mutant showed normal asexual blood stage proliferation and gametocyte production. However, the mutant displayed a moderate decrease in mature ookinete formation. The mature-looking mutant ookinetes lost the crescent shape and had an impaired gliding ability compared to the WT. As a consequence, the aprp4 mutant produced significantly decreased numbers of midgut oocysts in the infected mosquitoes. These defects caused by depletion of either APRp4 were in concordance with the phenotype of the apr2 mutant.
Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
Difference from wild-type
RMgm-5289
The mutant displayed a moderate decrease in mature ookinete formation. The mature-looking mutant ookinetes lost the crescent shape and had an impaired gliding ability compared to the WT. As a consequence, the aprp4 mutant produced significantly decreased numbers of midgut oocysts in the infected mosquitoes. These defects caused by depletion of either APRp4 were in concordance with the phenotype of the apr2 mutant.
Imported from RMgmDB

More information

PlasmoDB PKNH_1227300
GeneDB PKNH_1227300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK14_2460w, PKH_125170
Orthologs PBANKA_1318500 , PCHAS_1321800 , PF3D7_1454800 , PVP01_1252200 , PVX_117740 , PY17X_1322300
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