Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1289 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-1127 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-1289 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-1127 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-1289 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-1127
Normal numbers of gametocytes. Exflagellation numbers are formed. Activated pbgamer male gametocytes produce morphologically normal and motile microgametes; however, the vast majority of them was unable to detach from the residual body of the gametocytes and remained attached to the exflagellation centers even 30 min post activation.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-1289
The mutants developed into ookinetes with normal conversion rates. However, the morphology of ookinetes appeared somewhat laterally longer than those of the wild-type parasites. Calculation of the heightwidth ratios of these ookinetes confirmed that they had abnormal morphologies.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-1127
(Strongly) reduced ookinete formation (18% compared to 72% in wild type)
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-1289
Strongly reduced oocyst production.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-1127
(Strongly) reduced ookinete formation (18% compared to 72% in wild type). (Strongly) reduced oocyst formation.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1289
Strongly reduced sporozoite production.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1127
(Strongly) reduced oocyst formation. (Strongly) reduced sporozoite formation.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1127
(Strongly) reduced sporozoite formation. However, sporozoites are infectious to mice (by mosquito-bite infection)
Imported from RMgmDB

More information

PlasmoDB PKNH_0114000
GeneDB PKNH_0114000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PK8_0420w, PKH_011340
Orthologs PBANKA_1225400 , PCHAS_1226000 , PF3D7_0805200 , PVP01_0115300 , PVX_093500 , PY17X_1228600
Google Scholar Search for all mentions of this gene