PF3D7_1418100 liver specific protein 1, putative (LISP1)

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible		 USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible		 RMgm-284 Imported from RMgmDB
P. berghei ANKA
Possible		 RMgm-279 Imported from RMgmDB
P. berghei ANKA
Possible		 RMgm-280 Imported from RMgmDB
P. berghei ANKA
Possible		 RMgm-237 Imported from RMgmDB
P. berghei ANKA
Possible		 PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible		 RMgm-4938 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference		 RMgm-284 Imported from RMgmDB
P. berghei ANKA Asexual
No difference		 RMgm-279 Imported from RMgmDB
P. berghei ANKA Asexual
No difference		 RMgm-280 Imported from RMgmDB
P. berghei ANKA Asexual
No difference		 RMgm-237 Imported from RMgmDB
P. berghei ANKA Asexual
No difference		 PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference		 RMgm-4938 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference		 RMgm-279 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference		 RMgm-280 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference		 RMgm-237 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference		 RMgm-4938 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference		 RMgm-279 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference		 RMgm-280 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference		 RMgm-237 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference		 RMgm-4938 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference		 RMgm-279 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference		 RMgm-280 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference		 RMgm-237 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference		 RMgm-4938 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference		 RMgm-279 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference		 RMgm-280 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference		 RMgm-237 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference		 RMgm-4938 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type		 RMgm-284
The phenotype of this mutant has not been analysed in detail. Analyses of other mutants lacking expression of LISP1 (RMgm-237, RMgm-279, RMgm-280) indicate that egress of merozoites from the mature liver schizont is impaired
 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type		 RMgm-279
By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.The number and size of liver schizonts in rats and in HepG2 cells of the mutant was comparable to those of wild type parasites. The number of merozoites in mutant liver schizonts was similar to the merozoite number in wild type schizonts. The number of merozoites released from liver schizonts was 10-fold reduced compared to wild type. Released mutant merozoites showed an infectivity to erythrocytes that was comparable to that of wild type merozoites.
 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type		 RMgm-280
By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.The number and size of liver schizonts in rats and in HepG2 cells of the mutant was comparable to those of wild type parasites.
 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type		 RMgm-237
By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.
 Imported from RMgmDB

More information

PlasmoDB PF3D7_1418100
GeneDB PF3D7_1418100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PF14_0179
Orthologs PBANKA_1024600 , PCHAS_1025400 , PKNH_1339900 , PVP01_1330800 , PVX_085550 , PY17X_1027000
Google Scholar Search for all mentions of this gene