Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-284 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-279 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-280 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-237 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4938 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-284 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-279 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-280 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-237 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4938 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-279 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-280 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-237 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4938 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-279 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-280 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-237 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-4938 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-279 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-280 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-237 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-4938 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-279 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-280 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-237 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-4938 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-284
The phenotype of this mutant has not been analysed in detail. Analyses of other mutants lacking expression of LISP1 (RMgm-237, RMgm-279, RMgm-280) indicate that egress of merozoites from the mature liver schizont is impaired
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-279
By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.The number and size of liver schizonts in rats and in HepG2 cells of the mutant was comparable to those of wild type parasites. The number of merozoites in mutant liver schizonts was similar to the merozoite number in wild type schizonts. The number of merozoites released from liver schizonts was 10-fold reduced compared to wild type. Released mutant merozoites showed an infectivity to erythrocytes that was comparable to that of wild type merozoites.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-280
By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.The number and size of liver schizonts in rats and in HepG2 cells of the mutant was comparable to those of wild type parasites.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-237
By analysis of blood stage parasitemia after intravenous injection of sporozoites, the mutant sporozoites showed a 15-fold decrease in infectivity.
Imported from RMgmDB

More information

PlasmoDB PCHAS_1025400
GeneDB PCHAS_1025400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000125.01.0, PC000155.03.0, PC000157.02.0, PC000539.03.0, PC000600.00.0, PC000856.03.0, PC300841.00.0, PCAS_102440, PCHAS_102540
Orthologs PBANKA_1024600 , PF3D7_1418100 , PKNH_1339900 , PVP01_1330800 , PVX_085550 , PY17X_1027000
Google Scholar Search for all mentions of this gene