Last updated 1 year ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
32890576
\"Gene disruption of SR10 leads to impaired intraerythrocytic replication and strongly reduces gametocyte numbers. \"
Theo Sanderson, Francis Crick Institute
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
http://plasmodb.org/plasmo/showComment.do?projectId=PlasmoDB&stableId=PF3D7_1215900&commentTargetId=gene#21500 Theo Sanderson, Wellcome Trust Sanger Institute
P. chabaudi chabaudi
Possible
RMgm-4839 Imported from RMgmDB
P. yoelii yoelii 17X
Possible
RMgm-4758 Imported from RMgmDB
P. yoelii yoelii 17X
Possible
RMgm-4838 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
32890576
\"Gene disruption of SR10 leads to impaired intraerythrocytic replication and strongly reduces gametocyte numbers. \"
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
Attenuated
32890576
\"Gene disruption of SR10 leads to impaired intraerythrocytic replication and strongly reduces gametocyte numbers. \"
Theo Sanderson, Francis Crick Institute
P. berghei ANKA Asexual
Attenuated
http://plasmodb.org/plasmo/showComment.do?projectId=PlasmoDB&stableId=PF3D7_1215900&commentTargetId=gene#21500 Theo Sanderson, Wellcome Trust Sanger Institute
P. yoelii yoelii 17X Asexual
No difference
RMgm-4758 Imported from RMgmDB
P. yoelii yoelii 17X Asexual
Difference from wild-type
RMgm-4838
The proportion of parasites at early trophozoite stage displayed weak daily rhythmicity in both the wild type and sr10KO clone (amplitude for P. yoelii wild type: 0.30 0.02 and P. yoelii sr10KO: 0.31 0.01), yet the intra-erythrocytic developmental cycle (IDC) duration was shorter in the sr10KO clone (sr10KO IDC duration 24.45 h; wild type IDC duration ~28 h).
Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
Difference from wild-type
RMgm-4758
(somewhat) higher production of gametocytes; (somewhat) lower exflagellation
Imported from RMgmDB

More information

PlasmoDB PF3D7_1215900
GeneDB PF3D7_1215900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) 2277.t00154, MAL12P1.153, PFL0765w
Orthologs PBANKA_1431600 , PCHAS_1433600 , PKNH_1435400 , PVP01_1434700 , PVX_123475 , PY17X_1433900
Google Scholar Search for all mentions of this gene