Last updated 1 month ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
28371168
Sproozoites don't invade salivary glands, those isolated from hemolymph are defective in cell-traversal and invasion
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
15811533 Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
28371168
Sproozoites don't invade salivary glands, those isolated from hemolymph are defective in cell-traversal and invasion
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Asexual
Possible
15811533 Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
No difference
28371168
Sproozoites don't invade salivary glands, those isolated from hemolymph are defective in cell-traversal and invasion
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Ookinete
No difference
28371168
Sproozoites don't invade salivary glands, those isolated from hemolymph are defective in cell-traversal and invasion
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Oocyst
No difference
28371168
Sproozoites don't invade salivary glands, those isolated from hemolymph are defective in cell-traversal and invasion
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Sporozoite
Attenuated
28371168
Sproozoites don't invade salivary glands, those isolated from hemolymph are defective in cell-traversal and invasion
Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

MAEBL localized with rhoptry proteins and on the merozoite surface and not with microneme proteins. Dual-label indirect immunofluorescence assays analyzed by scanning confocal laser microscopy are shown in each row of images, using primary antibodies against a rhoptry and microneme protein. In each row, the immunolocalization pattern for the first protein listed is in green in the first left-hand panel and the second protein listed is the second panel shown in red. The third panel is the merged image of the first two panels, the final right-hand panel is the brightfield image. Color was assigned electronically. Markers: RhopH2 PFI1445w; EBA-175 MAL7P1.176; RAP1 PFE0080c.Blair PL, Kappe SH, Maciel JE, Balu B, Adams JH. Plasmodium falciparum MAEBL is a unique member of the ebl family. Mol Biochem Parasitol. 2002 122:35-44. Copyright Elsevier 2009.

See original on MMP

Phase contrast photograph of P. falciparum schizonts and free merozoites (100x) showing the reactivity of the mouse polyclonal anti-r-PfM2. (B) IFA reactivity of the mouse anti-r-PfM2 serum with methanol fixed late stage schizonts and free merozoites of P. falciparum 3D7 clone (100x). (C) IFA reactivity to air dried P. falciparum sporozoites (100x) using mouse anti-r-PfM2 antibody. Apical punctate fluorescence was observed in free merozoites and in late-stage schizonts. Positive fluorescence was also recorded on the surface of anopheles salivary gland sporozoites.Ghai M, Dutta S, Hall T, Freilich D, Ockenhouse CF. Identification, expression, and functional characterization of MAEBL, a sporozoite and asexual blood stage chimeric erythrocyte-binding protein of Plasmodium falciparum. Mol Biochem Parasitol. 2002 123:35-45. Copyright Elsevier

See original on MMP

More information

PlasmoDB PF3D7_1147800
GeneDB PF3D7_1147800
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PF11_0486, PF3D7_1147800.1, PF3D7_1147800.2
Orthologs PBANKA_0901300 , PBANKA_0901300 , PCHAS_0702500 , PKNH_0945700 , PVP01_0948400 , PVX_092975
Google Scholar Search for all mentions of this gene