PF3D7_0923800 thioredoxin reductase (TRXR)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Refractory |
26060916 | Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. falciparum 3D7 |
Refractory |
12004069 | Theo Sanderson, Francis Crick Institute | |
| P. berghei ANKA |
Possible |
RMgm-586 | Imported from RMgmDB | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-586 | Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-586 | Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
No difference |
RMgm-586 | Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-586
Normal numbers of oocysts. Total number of midgut sporozoites was lower compared to midgut-sporozoite production of wild type parasites. The number of salivary gland sporozoites was comparable to wild type. |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-586
Normal numbers of oocysts. Total number of midgut sporozoites was lower compared to midgut-sporozoite production of wild type parasites. The number of salivary gland sporozoites was comparable to wild type. In vivo and in vitro infectivity (as measured by prepatent period in mice and in vitro development in HuH7 hepatoma cells) of isolated sporozoites was comparable to that of wild type sporozoites. Infectivity of mosquitoes infected with mutant parasites was lower than that of mosquitoes infected with wild type parasites |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-586
In vivo and in vitro infectivity (as measured by prepatent period in mice and in vitro development in HuH7 hepatoma cells) of isolated sporozoites was comparable to that of wild type sporozoites. Infectivity of mosquitoes infected with mutant parasites was lower than that of mosquitoes infected with wild type parasites |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
Dissection of the dual localization of P. falciparum TrxR. (A) Dual localization (cytosol and mitochondria) of TrxR-GFP effected by a newly discovered N-terminal extension/leader. (B) Mitochondrial targeting of a construct (TrxR-N76-GFP) containing solely the TrxR 59-extension.Kehr S, Sturm N, Rahlfs S, Przyborski JM, Becker K. Compartmentation of redox metabolism in malaria parasites. PLoS Pathog. 2010 Dec 23;6(12):e1001242.
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| PlasmoDB | PF3D7_0923800 |
| GeneDB | PF3D7_0923800 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PF3D7_0923800.1, PF3D7_0923800.2, PFI1170c |
| Orthologs | PBANKA_0824700 , PCHAS_0825000 , PKNH_0721800 , PVP01_0722300 , PVX_099600 , PY17X_0828000 |
| Google Scholar | Search for all mentions of this gene |