PF3D7_0807400 coenzyme Q-binding protein COQ10 homolog, mitochondrial (COQ10)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
Imaging data (from Malaria Metabolic Pathways)
Localization of PfCoq10 to the mitochondria. (A) Live fluorescence microscopy of PfCoq10-GFP expressing parasites. (B) immunofluorescence assay of parasites expressing HA-tagged PfCoq10 constructs. Parasites showed strong expression of PfCoq10-GFP that colocalized with Mitotracker (A). These results were further confirmed by immunofluorescence assays in parasites expressing PfCoq10-3HA. In contrast, PfCoq10Δ34 immunofluorescence showed mainly punctate staining in the cytoplasm, confirming that an N-terminal targeting sequence is required for mitochondrial localization (B).Jenkins BJ, Daly TM, Morrisey JM, Mather MW, Vaidya AB, Bergman LW. Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p. PLoS One. 2016 11(3):e0152197
See original on MMPMore information
| PlasmoDB | PF3D7_0807400 |
| GeneDB | PF3D7_0807400 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | MAL8P1.300 |
| Orthologs | PBANKA_1223200 , PCHAS_1223800 , PKNH_0111400 , PVP01_0113000 , PVX_088175 , PY17X_1226400 |
| Google Scholar | Search for all mentions of this gene |