Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Localization of PfCoq10 to the mitochondria. (A) Live fluorescence microscopy of PfCoq10-GFP expressing parasites. (B) immunofluorescence assay of parasites expressing HA-tagged PfCoq10 constructs. Parasites showed strong expression of PfCoq10-GFP that colocalized with Mitotracker (A). These results were further confirmed by immunofluorescence assays in parasites expressing PfCoq10-3HA. In contrast, PfCoq10Δ34 immunofluorescence showed mainly punctate staining in the cytoplasm, confirming that an N-terminal targeting sequence is required for mitochondrial localization (B).Jenkins BJ, Daly TM, Morrisey JM, Mather MW, Vaidya AB, Bergman LW. Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p. PLoS One. 2016 11(3):e0152197

See original on MMP

More information

PlasmoDB PBANKA_1223200
GeneDB PBANKA_1223200
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PBANKA_122320
Orthologs PCHAS_1223800 , PF3D7_0807400 , PKNH_0111400 , PVP01_0113000 , PVX_088175 , PY17X_1226400
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