Last updated 1 year ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
28106035 (Spontaneous loss, not experimental genetics)
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

PfPARE is expressed in asexual parasites. Live fluorescence microscopy with GFP-tagged PfPARE shows the protein is in the cytoplasm. Scale bar 5 mm. The intensity of the GFP fluorescence was weak in ring stages and increased with parasite maturity.Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE. Esterase mutation is a mechanism of resistance to antimalarial compounds. Nat Commun. 2017 8:14240.

See original on MMP

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