Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
RMgm-657 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-657
Infectivity of mutant sporozoites as measured by the prepatent period after infection of mice is strongly reduced. After intravenous injection of sporozoites ~70% of the mice did not develop a blood stage development; the other mice showed a delay of the prepatent period of at least 4 days. Infectivity of sporozoites as measured by invasion of hepatocytes is comparable to that of wild type sporozoites. Invasion of hepatocytes in vitro by sporozoites was normal and liver stages developed into 'mature' liver schizonts. The formation of merosomes was strongly reduced compared to wild type liver schizonts.
Imported from RMgmDB

More information

PlasmoDB PF3D7_0602300
GeneDB PF3D7_0602300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) 2270.t00292, MAL6P1.26, PFF0110w
Orthologs PBANKA_0101100 , PCHAS_0101800 , PKNH_1148400 , PVP01_1146600 , PVX_113280 , PY17X_0102700
Google Scholar Search for all mentions of this gene