Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-657 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) Imported from PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-657 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-657
Infectivity of mutant sporozoites as measured by the prepatent period after infection of mice is strongly reduced. After intravenous injection of sporozoites ~70% of the mice did not develop a blood stage development; the other mice showed a delay of the prepatent period of at least 4 days. Infectivity of sporozoites as measured by invasion of hepatocytes is comparable to that of wild type sporozoites. Invasion of hepatocytes in vitro by sporozoites was normal and liver stages developed into 'mature' liver schizonts. The formation of merosomes was strongly reduced compared to wild type liver schizonts.
Imported from RMgmDB

More information

PlasmoDB PBANKA_0101100
GeneDB PBANKA_0101100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB001116.02.0, PBANKA_010110
Orthologs PCHAS_0101800 , PF3D7_0602300 , PKNH_1148400 , PVP01_1146600 , PVX_113280 , PY17X_0102700
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