Last updated 2 months ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
34750454 (Conditional)
Di-Cre based deletion. \'Deletion resulted in a significant reduction of parasite growth in vitro, reduced ubiquitylation of the Lys63 residue of ubiquitin attached to protein substrates, and an increased sensitivity of the parasite to both the mutagen, methyl methanesulfonate and the antimalarial drug dihydroartemisinin (DHA), but not chloroquine.\'
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PF3D7_0527100
GeneDB PF3D7_0527100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL5P1.270, PFE1350c
Orthologs PBANKA_1241900 , PCHAS_1242300 , PKNH_1005600 , PVP01_1006700 , PVX_079885 , PY17X_1245100
Google Scholar Search for all mentions of this gene