Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
34750454
Di-Cre based deletion. \'Deletion resulted in a significant reduction of parasite growth in vitro, reduced ubiquitylation of the Lys63 residue of ubiquitin attached to protein substrates, and an increased sensitivity of the parasite to both the mutagen, methyl methanesulfonate and the antimalarial drug dihydroartemisinin (DHA), but not chloroquine.\'
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PCHAS_1242300
GeneDB PCHAS_1242300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000321.01.0, PCAS_124230, PCHAS_124230
Orthologs PBANKA_1241900 , PF3D7_0527100 , PKNH_1005600 , PVP01_1006700 , PVX_079885 , PY17X_1245100
Google Scholar Search for all mentions of this gene