Last updated 2 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA
Refractory
RMgm-555 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Images captured by laser scanning confocal microscopy show substantial co-localization of Pfcrk-3 (green) with nuclear-localized histones (red). P. falciparum 3D7 parasites were fixed with 4% paraformaldehyde / 0.0075% glutaraldehyde and probed with chicken IgY anti-Pfcrk-3 and mouse IgG anti-histone antibodies. The data in each row represent the fluorescence profile in ring stage parasites, early trophozoites, late trophozoites, and schizonts, respectively. In some ring-stage parasites (e.g. the top row appears to localize at the periphery of the nucleus, DIC: Differential interference contrast. Scale bar = 2 mm, except for the top row, where it is 5 mm.Halbert J, Ayong L, Equinet L, Le Roch K, Hardy M, Goldring D, Reininger L, Waters N, Chakrabarti D, Doerig C. A Plasmodium falciparum transcriptional CDK-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity. Eukaryot Cell. 2010 9:952-959.

See original on MMP

More information

PlasmoDB PF3D7_0415300
GeneDB PF3D7_0415300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL4P1.143, PFD0740w
Orthologs PBANKA_0717300 , PCHAS_0726400 , PKNH_0506900 , PVP01_0521800 , PVX_089720 , PY17X_0717500
Google Scholar Search for all mentions of this gene