Last updated 3 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Refractory
RMgm-555 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Images captured by laser scanning confocal microscopy show substantial co-localization of Pfcrk-3 (green) with nuclear-localized histones (red). P. falciparum 3D7 parasites were fixed with 4% paraformaldehyde / 0.0075% glutaraldehyde and probed with chicken IgY anti-Pfcrk-3 and mouse IgG anti-histone antibodies. The data in each row represent the fluorescence profile in ring stage parasites, early trophozoites, late trophozoites, and schizonts, respectively. In some ring-stage parasites (e.g. the top row appears to localize at the periphery of the nucleus, DIC: Differential interference contrast. Scale bar = 2 mm, except for the top row, where it is 5 mm.Halbert J, Ayong L, Equinet L, Le Roch K, Hardy M, Goldring D, Reininger L, Waters N, Chakrabarti D, Doerig C. A Plasmodium falciparum transcriptional CDK-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity. Eukaryot Cell. 2010 9:952-959.

See original on MMP

More information

PlasmoDB PF3D7_0415300
GeneDB PF3D7_0415300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL4P1.143, PFD0740w
Orthologs PBANKA_0717300 , PCHAS_0726400 , PKNH_0506900 , PVP01_0521800 , PVX_089720 , PY17X_0717500
Google Scholar Search for all mentions of this gene