Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-555 Imported from RMgmDB
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Refractory
20305001 Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Images captured by laser scanning confocal microscopy show substantial co-localization of Pfcrk-3 (green) with nuclear-localized histones (red). P. falciparum 3D7 parasites were fixed with 4% paraformaldehyde / 0.0075% glutaraldehyde and probed with chicken IgY anti-Pfcrk-3 and mouse IgG anti-histone antibodies. The data in each row represent the fluorescence profile in ring stage parasites, early trophozoites, late trophozoites, and schizonts, respectively. In some ring-stage parasites (e.g. the top row appears to localize at the periphery of the nucleus, DIC: Differential interference contrast. Scale bar = 2 mm, except for the top row, where it is 5 mm.Halbert J, Ayong L, Equinet L, Le Roch K, Hardy M, Goldring D, Reininger L, Waters N, Chakrabarti D, Doerig C. A Plasmodium falciparum transcriptional CDK-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity. Eukaryot Cell. 2010 9:952-959.

See original on MMP

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