Last updated 9 months ago

Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-34 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-34
Normal numbers of salivary gland sporozoites are produced. Sporozoites show a gliding motility similar to wild type sporozoites. Invasion of hepatocytes is significantly reduced (see phenotype 'liver stage').
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-34
In vitro invasion of hepatocytes by the sporozoites is significantly reduced (35-38% reduction in number of completely intracellular sporozoites compared to wild type sporozoites). Invaded sporozoites develop normally inside HepG2 cells into mature liver schizonts.In vivo a 40-80% reduction in liver infection is observed after infection of C57BL/6 mice by intraveneous inoculation of sporozoites.
Imported from RMgmDB

More information

PlasmoDB PF3D7_0104000
GeneDB PF3D7_0104000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL1P1.30, PFA0200w
Orthologs PBANKA_0209100 , PCHAS_0207500 , PKNH_0209500 , PVP01_0210700 , PVX_081560 , PY17X_0210500
Google Scholar Search for all mentions of this gene