Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-34 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-34 Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-34
Normal numbers of salivary gland sporozoites are produced. Sporozoites show a gliding motility similar to wild type sporozoites. Invasion of hepatocytes is significantly reduced (see phenotype 'liver stage').
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-34
In vitro invasion of hepatocytes by the sporozoites is significantly reduced (35-38% reduction in number of completely intracellular sporozoites compared to wild type sporozoites). Invaded sporozoites develop normally inside HepG2 cells into mature liver schizonts.In vivo a 40-80% reduction in liver infection is observed after infection of C57BL/6 mice by intraveneous inoculation of sporozoites.
Imported from RMgmDB

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