Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-587 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-404 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-403 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-587
The mutant showed a slight delay in initial proliferation of blood stages in mice.
Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-404 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-403 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-587 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-404 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-403 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-587 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-404 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-403 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-587
Mutants produced lower numbers of oocysts in comparison with wild type parasites (although the differences were not significant). Mutant oocysts were significantly smaller than wild type oocysts and no sporozoites were formed.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-404
Mutant oocysts numbers in Anopheles stephensi, counted at day 10-12 post infection, were slightly lower than those produced by wild type parasites and the size of mutant oocysts at day 10-12 was significantly smaller compared to the size of wild type oocysts with a maximum size that is comparable to immature 6-8 days wt oocysts.The small oocysts that are present at day 10-12 showed a highly vacuolated cytoplasm and the absence of sporozoite formation. No sporozoites were observed in A. stephensi salivary glands at day 21-22 post infection
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-403
Mutant oocysts numbers in Anopheles stephensi, counted at day 10-12 post infection, were slightly lower than those produced by wild type parasites and the size of mutant oocysts at day 10-12 was significantly smaller compared to the size of wild type oocysts with a maximum size that is comparable to immature 6-8 days wt oocysts.The small oocysts that are present at day 10-12 showed a highly vacuolated cytoplasm and the absence of sporozoite formation. No sporozoites were observed in A. stephensi salivary glands at day 21-22 post infection
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-587
No production of oocyst- or salivary gland sporozoites
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-404
The small oocysts that are present at day 10-12 showed a highly vacuolated cytoplasm and the absence of sporozoite formation. No sporozoites were observed in A. stephensi salivary glands at day 21-22 post infection
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-403
The small oocysts that are present at day 10-12 showed a highly vacuolated cytoplasm and the absence of sporozoite formation. No sporozoites were observed in A. stephensi salivary glands at day 21-22 post infection
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-587
No production of oocyst- or salivary gland sporozoites. Infected mosquitoes were unable to infect mice by mosquito bite
Imported from RMgmDB

More information

PlasmoDB PCHAS_1024200
GeneDB PCHAS_1024200
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000998.02.0, PC001414.02.0, PCAS_102320, PCHAS_102420
Orthologs PBANKA_1023400 , PF3D7_1419800 , PF3D7_1419800 , PKNH_1338200 , PVP01_1329100 , PVX_085490 , PY17X_1025300
Google Scholar Search for all mentions of this gene