Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
33124706 (Knock down)
By conditionally depleting PfMCMBP, we disrupt nuclear morphology and parasite proliferation without causing a block in DNA replication. By immunofluorescence microscopy, we show that PfMCMBP depletion promotes the formation of mitotic spindle microtubules with extensions to more than one DNA focus and abnormal centrin distribution. Strikingly, PfMCMBP‐deficient parasites complete cytokinesis and form aneuploid merozoites with variable cellular and nuclear sizes. Our study demonstrates that the parasite lacks a robust checkpoint response to prevent cytokinesis following aberrant karyokinesis.
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PBANKA_1030500
GeneDB PBANKA_1030500
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000323.00.0, PB001172.00.0, PB100587.00.0, PBANKA_103050
Orthologs PCHAS_1031300 , PF3D7_1412100 , PKNH_1346200 , PVP01_1336800 , PVX_085850 , PY17X_1032900
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