Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1271 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-1270 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-1271
Reduced growth/multiplication of asexual blood stages
Imported from RMgmDB
P. berghei ANKA Asexual
Difference from wild-type
RMgm-1270
Reduced growth/multiplication of asexual blood stages
Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-1271
Reduced gametocyte production
Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-1270
Reduced gametocyte production
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-1270
Strongly reduced ookinete formation
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-1271
Strongly reduced ookinete formation
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-1270
Strongly reduced oocyst formation
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-1271
Strongly reduced oocyst formation
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1270
No sporozoite formation
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1271
No sporozoite formation
Imported from RMgmDB
P. falciparum 3D7 Asexual
Attenuated
24453970 (Conditional)
\" To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(Δpepc) ), which was only achievable when malate, a reduction product of oxaloacetate, was added to the growth medium. D10(Δpepc) had a severe growth defect in vitro, which was partially reversed by addition of malate or fumarate, suggesting that pepc may be essential in vivo. \"
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PBANKA_1017900
GeneDB PBANKA_1017900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000844.03.0, PBANKA_101790
Orthologs PCHAS_1018700 , PF3D7_1426700 , PKNH_1332000 , PVP01_1322600 , PVX_085200 , PY17X_1019400
Google Scholar Search for all mentions of this gene