Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) Imported from PlasmoGEM
P. falciparum 3D7
Possible
29354648
The Glo1 activity of clonal 3D7Δglo1 parasites dropped by approximately 90% resulting in an increased susceptibility towards external glyoxal. None of the clonal knockout strains had a suspicious morphology during asexual blood-stage development when compared to the wild-type 3D7 strain. Even though blood-stage growth rates appeared to be slightly reduced for single knockout clones, differences to the wild-type strain were not significant according to statistical analyses.
,
P. falciparum 3D7
Possible
29354648
Compared to its parental line, 3D7Δglo1 parasites formed reduced numbers of gametocytes in more than three independent experiments, when these were quantified 14 days after setting up the gametocyte cultures.
Marcel Deponte, Department of Chemistry/Biochemistry, University of Kaiserslautern

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) Imported from PlasmoGEM
P. falciparum 3D7 Asexual
No difference
29354648
The Glo1 activity of clonal 3D7Δglo1 parasites dropped by approximately 90% resulting in an increased susceptibility towards external glyoxal. None of the clonal knockout strains had a suspicious morphology during asexual blood-stage development when compared to the wild-type 3D7 strain. Even though blood-stage growth rates appeared to be slightly reduced for single knockout clones, differences to the wild-type strain were not significant according to statistical analyses.
,
P. falciparum 3D7 Asexual
No difference
29354648
Compared to its parental line, 3D7Δglo1 parasites formed reduced numbers of gametocytes in more than three independent experiments, when these were quantified 14 days after setting up the gametocyte cultures.
Marcel Deponte, Department of Chemistry/Biochemistry, University of Kaiserslautern
P. falciparum 3D7 Gametocyte
Difference from wild-type
29354648
The Glo1 activity of clonal 3D7Δglo1 parasites dropped by approximately 90% resulting in an increased susceptibility towards external glyoxal. None of the clonal knockout strains had a suspicious morphology during asexual blood-stage development when compared to the wild-type 3D7 strain. Even though blood-stage growth rates appeared to be slightly reduced for single knockout clones, differences to the wild-type strain were not significant according to statistical analyses.
,
P. falciparum 3D7 Gametocyte
Difference from wild-type
29354648
Compared to its parental line, 3D7Δglo1 parasites formed reduced numbers of gametocytes in more than three independent experiments, when these were quantified 14 days after setting up the gametocyte cultures.
Marcel Deponte, Department of Chemistry/Biochemistry, University of Kaiserslautern

More information

PlasmoDB PBANKA_0933900
GeneDB PBANKA_0933900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000003.03.0, PBANKA_093390
Orthologs PCHAS_0910400 , PF3D7_1113700 , PKNH_0911300 , PVP01_0914500 , PVX_091330 , PY17X_0935900
Google Scholar Search for all mentions of this gene