normal production of gametocytes; normal exflagellation

Reduced growth/multiplication of asexual blood stages.Parasitemias in Pbvit- infected mice were significantly reduced, when compared with those in mice infected with wild-type (wt) parasites. Furthermore, C57Bl/6 J mice infected with Pbvit- parasites (104 infected RBC i.v.) survived significantly longer compared with mice infected with wt parasites.

Reduced liver stage development.A significant reduction in parasite liver load was detected after Pbvit- sporozoite infection. The observed reduction in parasite liver load was due to a lower number of infected hepatocytes, as well as moderate reduction in size of developing Pbvit- exoerythrocytic parasite formsEEFs.