Images captured by laser scanning confocal microscopy show substantial co-localization of Pfcrk-3 (green) with nuclear-localized histones (red). P. falciparum 3D7 parasites were fixed with 4% paraformaldehyde / 0.0075% glutaraldehyde and probed with chicken IgY anti-Pfcrk-3 and mouse IgG anti-histone antibodies. The data in each row represent the fluorescence profile in ring stage parasites, early trophozoites, late trophozoites, and schizonts, respectively. In some ring-stage parasites (e.g. the top row appears to localize at the periphery of the nucleus, DIC: Differential interference contrast. Scale bar = 2 mm, except for the top row, where it is 5 mm.Halbert J, Ayong L, Equinet L, Le Roch K, Hardy M, Goldring D, Reininger L, Waters N, Chakrabarti D, Doerig C. A Plasmodium falciparum transcriptional CDK-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity. Eukaryot Cell. 2010 9:952-959.