PVX_111055 haloacid dehalogenase-like hydrolase, putative (HAD1)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. falciparum 3D7 | Asexual |
Possible |
25058848 (Spontaneous loss, not experimental genetics)
Truncations and other LOF mutations |
Theo Sanderson, Wellcome Trust Sanger Institute |
Imaging data (from Malaria Metabolic Pathways)
PfHAD1 is expressed in blood-stage parasites and is localized to the parasite cytoplasm. Immunofluorescence confocal microscopy of ACPLGFP trophozoite and schizont, stained with aGFP and aPfHAD1 antibodies and Hoechst 33258 nuclear stain. Scale bars, 2 mm. Lower panel: PfHAD1-GFP localization is similar to that of PfHAD1 (Upper panel). Shown is live microscopy of AM1 Hsp110:PfHAD1-GFP trophozoite and schizont, stained with Hoechst 33258 nuclear stain. Scale bars represent 2 μm.Guggisberg AM, Park J, Edwards RL, Kelly ML, Hodge DM, Tolia NH, Odom AR. A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun. 2014 24;5:4467.
See original on MMPMore information
| PlasmoDB | PVX_111055 |
| GeneDB | PVX_111055 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | Pv111055 |
| Orthologs | PBANKA_0517200 , PCHAS_0517300 , PF3D7_1033400 , PKNH_0618200 , PVP01_0618500 , PY17X_0518300 |
| Google Scholar | Search for all mentions of this gene |