PVP01_0947200 oocyst rupture protein 1, putative (ORP1)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-4059 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-4059 | Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. berghei ANKA | Gametocyte |
No difference |
RMgm-4059 | Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-4059
Slightly higher oocyst production compared to wild type. Sporozoites are formed inside oocysts. Oocysts do not rupture and oocysts do not release sporozoites. |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-4059
Slightly higher oocyst production compared to wild type. Sporozoites are formed inside oocysts. Oocysts do not rupture and oocysts do not release sporozoites. |
Imported from RMgmDB |
| P. berghei ANKA | Liver |
Difference from wild-type |
RMgm-4059
No infection of mice after mosquito bite. No infection of mice after infection with sporozoites that are artificially released from oocysts (motility of these sporozoites was not tested/reported) |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
The cellular localization of PfNF-YB was examined in ring, trophozoite and schizont stages of intra-erythrocytic cycle. PfNF-YB was localized at both cytoplasm and nucleus. Immunofluorescence was carried out with the anti-PfNF-YB antibody (green), and nuclear DNA was stained with TOPRO-3 (blue) and the RBC membrane bordering with WGA (red). The confocal images exhibited a specific staining to parasites and displayed localization in both cytoplasm and nucleus in all stages. Scale bar = 5 mm.Lima WR, Moraes M, Alves E, Azevedo MF, Passos DO, Garcia CR. The PfNF-YB transcription factor is a downstream target of melatonin and cAMP signalling in the human malaria parasite Plasmodium falciparum. J Pineal Res. 2012 54(2):145-53
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| PlasmoDB | PVP01_0947200 |
| GeneDB | PVP01_0947200 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | null |
| Orthologs | PBANKA_0902500 , PCHAS_0703800 , PF3D7_1146600 , PKNH_0944400 , PVX_092925 , PY17X_0903900 |
| Google Scholar | Search for all mentions of this gene |