| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-5069 | Imported from RMgmDB | |
| P. falciparum 3D7 |
Possible |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. falciparum 3D7 |
Possible |
35465336 \"Parasites that carry a deletion of MaCFET (Pfmacfet¯), developed normally as asexual stages, indicating that its function is not essential for the asexual proliferation of the parasite in vitro. Furthermore, Pfmacfet¯ male and female gametocytes developed normally and underwent activation to form microgametes and macrogametes. However, by utilizing genetic crosses, we demonstrate that Pfmacfet¯ parasites suffer a complete female-specific defect in successful fertilization. Therefore, PfMaCFET is a critical female-contributed factor for parasite transmission to the mosquito.\" |
Theo Sanderson, Francis Crick Institute | |
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
No difference |
RMgm-5069 | Imported from RMgmDB |
| P. falciparum 3D7 | Asexual |
No difference |
35465336 \"Parasites that carry a deletion of MaCFET (Pfmacfet¯), developed normally as asexual stages, indicating that its function is not essential for the asexual proliferation of the parasite in vitro. Furthermore, Pfmacfet¯ male and female gametocytes developed normally and underwent activation to form microgametes and macrogametes. However, by utilizing genetic crosses, we demonstrate that Pfmacfet¯ parasites suffer a complete female-specific defect in successful fertilization. Therefore, PfMaCFET is a critical female-contributed factor for parasite transmission to the mosquito.\" |
Theo Sanderson, Francis Crick Institute |
| P. berghei ANKA | Gametocyte |
Difference from wild-type |
RMgm-5069
Infertile females, fertile males. |
Imported from RMgmDB |
| P. falciparum 3D7 | Gametocyte |
Attenuated |
35465336 \"Parasites that carry a deletion of MaCFET (Pfmacfet¯), developed normally as asexual stages, indicating that its function is not essential for the asexual proliferation of the parasite in vitro. Furthermore, Pfmacfet¯ male and female gametocytes developed normally and underwent activation to form microgametes and macrogametes. However, by utilizing genetic crosses, we demonstrate that Pfmacfet¯ parasites suffer a complete female-specific defect in successful fertilization. Therefore, PfMaCFET is a critical female-contributed factor for parasite transmission to the mosquito.\" |
Theo Sanderson, Francis Crick Institute |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-5069
Infertile females, fertile males.Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-5069
Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes |
Imported from RMgmDB |
| PlasmoDB | PKNH_1460500 |
| GeneDB | PKNH_1460500 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PK12_3990c, PKH_145840 |
| Orthologs | PBANKA_1454800 , PCHAS_1457100 , PF3D7_1241400 , PVP01_1458500 , PVX_100970 , PY17X_1457300 |
| Google Scholar | Search for all mentions of this gene |