PKNH_1422300 serpentine receptor, putative (SR25)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Refractory |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Possible |
28842684 Decreased parasitaemia and metacaspase expression on exposure to sodium nitroprusside. The protein appears to play a role in volume regulation. |
Theo Sanderson, Wellcome Trust Sanger Institute | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. falciparum 3D7 |
Possible |
32824696 More sensitive to 1,2,3-Triazole Compounds |
Theo Sanderson, Francis Crick Institute | |
| P. yoelii yoelii 17X |
Refractory |
RMgm-4799 | Imported from RMgmDB | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
Attenuated |
28842684 Decreased parasitaemia and metacaspase expression on exposure to sodium nitroprusside. The protein appears to play a role in volume regulation. |
Theo Sanderson, Wellcome Trust Sanger Institute |
| P. falciparum 3D7 | Asexual |
Attenuated |
32824696 More sensitive to 1,2,3-Triazole Compounds |
Theo Sanderson, Francis Crick Institute |
Imaging data (from Malaria Metabolic Pathways)
Intraerythrocytic expression of PfSR25 and gene disruption. IFA of PfSR25 during erythrocyte stages was done at ring; trophozoite; schizont and merozoite stage. PfMSP1 was used to confirm the co-localization of SR25. PfSR25 was clearly detected in RBC infective parasite stage, i.e. the merozoite. Co-localization with Plasmodium surface protein MSP-1 reveals that SR25 expression at parasite membrane.Moraes MS, Budu A, Singh MK, Borges-Pereira L, Levano-Garcia J, Currà C, Picci L, Pace T, Ponzi M, Pozzan T, Garcia CRS. Plasmodium falciparum GPCR-like receptor SR25 mediates extracellular K(+) sensing coupled to Ca(2+) signaling and stress survival. Sci Rep. 2017 7(1):9545.
See original on MMPMore information
| PlasmoDB | PKNH_1422300 |
| GeneDB | PKNH_1422300 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PK13_2120w, PKH_142070 |
| Orthologs | PBANKA_1420000 , PCHAS_1421800 , PF3D7_0713400 , PVP01_1422500 , PVX_122895 , PY17X_1421700 |
| Google Scholar | Search for all mentions of this gene |