Normal numbers of oocysts are produced. On day 10 after infection melanized oocysts are present in 55-65% of QC-null infected mosquitoes (1-85 melanized oocysts/mosquito), while such oocysts were absent in WT-infected mosquitoes

Normal numbers of oocysts are produced. On day 10 after infection melanized oocysts are present in 55-65% of QC-null infected mosquitoes (1-85 melanized oocysts/mosquito), while such oocysts were absent in WT-infected mosquitoes

Normal numbers of oocysts are produced. On day 10 after infection melanized oocysts are present in 55-65% of QC-null infected mosquitoes (1-85 melanized oocysts/mosquito), while such oocysts were absent in WT-infected mosquitoes

Reduced numbers of salivary gland sporozoites. Salivary gland sporozoites show wild-type morphology, motility and infectivity to hepatocytes in vitro. Light-microscopy analysis of oocysts between day 14 and 21 showed the presence of aberrant, enlarged, melanized sporozoites, either still inside or during release from oocysts.On day 21 p.i. non-motile, enlarged sporozoites covered by melanin were found in the hemocoel, often in clusters or attached to salivary glands. In contrast, most QC-null sporozoites inside salivary glands had a WT-like morphology, i.e. long and slender, without signs of melanization.

Reduced numbers of salivary gland sporozoites. Salivary gland sporozoites show wild-type morphology, motility and infectivity to hepatocytes in vitro. Light-microscopy analysis of oocysts between day 14 and 21 showed the presence of aberrant, enlarged, melanized sporozoites, either still inside or during release from oocysts.On day 21 p.i. non-motile, enlarged sporozoites covered by melanin were found in the hemocoel, often in clusters or attached to salivary glands. In contrast, most QC-null sporozoites inside salivary glands had a WT-like morphology, i.e. long and slender, without signs of melanization.

Reduced numbers of salivary gland sporozoites. Salivary gland sporozoites show wild-type morphology, motility and infectivity to hepatocytes in vitro. Light-microscopy analysis of oocysts between day 14 and 21 showed the presence of aberrant, enlarged, melanized sporozoites, either still inside or during release from oocysts.On day 21 p.i. non-motile, enlarged sporozoites covered by melanin were found in the hemocoel, often in clusters or attached to salivary glands. In contrast, most QC-null sporozoites inside salivary glands had a WT-like morphology, i.e. long and slender, without signs of melanization.

Reduced numbers of salivary gland sporozoites. Salivary gland sporozoites show wild-type morphology, motility and infectivity to hepatocytes in vitro. Wild type development of liver stages in vitro.

Reduced numbers of salivary gland sporozoites. Salivary gland sporozoites show wild-type morphology, motility and infectivity to hepatocytes in vitro. Wild type development of liver stages in vitro.

Reduced numbers of salivary gland sporozoites. Salivary gland sporozoites show wild-type morphology, motility and infectivity to hepatocytes in vitro. Wild type development of liver stages in vitro.