PKNH_0819400 protein kinase, putative
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Refractory |
RMgm-575 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. yoelii yoelii 17X |
Possible |
RMgm-4708 | Imported from RMgmDB | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. yoelii yoelii 17X | Asexual |
Difference from wild-type |
RMgm-4708
Reduced growth/multiplication of asexual blood stages. Evidence is provided for reduced invasion of merozoites. |
Imported from RMgmDB |
| P. yoelii yoelii 17X | Gametocyte |
Difference from wild-type |
RMgm-4708
Normal production of male and female gametocytes. Normal egress of both male and female gametocytes from their host red blood cells after activation. Normal exflagellation rate (i.e. male gamete formation); however, exflagellating males showed (strongly) reduced formation of the characteristic exflagellation centers, i.e. exflagellating males surrounded/attached to uninfected cells. |
Imported from RMgmDB |
| P. yoelii yoelii 17X | Oocyst |
Difference from wild-type |
RMgm-4708
Strongly reduces formation of oocysts |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization. Shown are proteins that revealed cytosolic (PFC0945w, PFI1565w’PF11_0190 and PFL2100w, apicoplast (PFE0145w), mitochondrial and other subcellular distribution but may be involved in invasion.Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.
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| PlasmoDB | PKNH_0819400 |
| GeneDB | PKNH_0819400 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PK3_1880w, PKH_081920 |
| Orthologs | PBANKA_1217100 , PCHAS_1217800 , PF3D7_0321400 , PVP01_0818800 , PVX_095165 , PY17X_1220300 |
| Google Scholar | Search for all mentions of this gene |