PKNH_0703800 exoribonuclease II, putative (RNaseII)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Refractory |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
Cell cycle arrest |
25043062 (Conditional)
drastic morphological changes in mature stages of the second cycle and were deficient in progressing to a third cycle |
Mehdi, Sanger |
Imaging data (from Malaria Metabolic Pathways)
Coimmunofluorescence assay of three plasmodial exoribonucleases and a core exosome member, PfRrp45, in ring-stage wild-type 3D7 parasites. The rabbit anti-PfRrp45, anti-PfRNase II, anti-PfRrp6 and mouse anti-PfDis3 antibodies were used in these assays. DAPI, 49,6-diamidino-2-phenylindole. Scale bar, 1 mm. Immunofluorescence assay (IFA) analysis revealed that PfRrp6 and PfRNase II localize as distinct foci at the nuclear periphery and that PfDis3 is localized in the cytoplasm adjacent to the nucleus at the ring stage .Zhang Q, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014 Jun 29. PMID:
See original on MMPMore information
| PlasmoDB | PKNH_0703800 |
| GeneDB | PKNH_0703800 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PK9_0330c, PKH_070330 |
| Orthologs | PBANKA_0415300 , PCHAS_0416200 , PF3D7_0906000 , PVP01_0704500 , PVX_098745 , PY17X_0418100 |
| Google Scholar | Search for all mentions of this gene |