Localization of PfMRScyt using antibodies directed against the N-terminal domain. The protein localizes in the cytoplasm for all asexual parasite stages. (D) Localization ofMRSapi, studied using antibodies against the anticodon binding domain. Localization of MRSapi in apicoplasts in three asexual stages (ring, trophozoite, and schizont) was verified.Hussain T, Yogavel M, Sharma A. Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases. Antimicrob Agents Chemother. 2015 Apr;59(4):1856-67.