PKNH_0510500 conserved Plasmodium protein, unknown function
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. berghei ANKA |
Possible |
RMgm-4143 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
Difference from wild-type |
RMgm-4143
Slightly reduced growth/multiplication of asexual blood stages. |
Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. berghei ANKA | Gametocyte |
Difference from wild-type |
RMgm-4143
Strongly reduced exflagellation (male gamete formation). Reduced DNA replication during male gamete formation (partially blocked at 1N; 50% of microgametocytes remained haploid; 40% of SOC1-KO microgametocytes reached the octoploid state). |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-4143
Strongly reduced exflagellation (male gamete formation). Reduced DNA replication during male gamete formation (partially blocked at 1N; 50% of microgametocytes remained haploid; 40% of SOC1-KO microgametocytes reached the octoploid state). |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
Functional characterisation of three identified substrates of CDPK4. (B) SOC1-3xHA shows a diffuse cytoplasmic distribution (scale bar = 2 mm) but interacts withCDPK4 and proteins of the MCM complex. (F) SOC3 colocalises with axonemal a-tubulin in exflagellating gametes. Scale bar = 2 mm.Fang H, Klages N, Baechler B, Hillner E, Yu L, Pardo M, Choudhary J, Brochet M. Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis. Elife. 2017 May 8;6. pii: e26524. PMID: 28481199
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| PlasmoDB | PKNH_0510500 |
| GeneDB | PKNH_0510500 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PK4_1400c, PKH_052220 |
| Orthologs | PBANKA_0720200 , PCHAS_0729200 , PF3D7_0418100 , PVP01_0527500 , PVX_089995 , PY17X_0720200 |
| Google Scholar | Search for all mentions of this gene |