PF3D7_1451800 sortilin
Disruptability [+]
No information reported yet. Please press the '+' button above to add some.Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. falciparum 3D7 | Asexual |
Attenuated |
29582546 (Knock down)
glmS knockdown gave 90% reduction of parasitaemia after two cycles. No merozoites formed in 50% of schizonts, despite normal nuclear division. Parasites could not recover if knockdown was removed after the onset of schizogony. Trafficking was severely disrupted (see details in paper). |
Theo Sanderson, Wellcome Trust Sanger Institute |
| P. falciparum 3D7 | Asexual |
Difference from wild-type |
PMID: 29582546 (Conditional)
Apical complex and IMC biogenesis is disrupted. Cytokinesis blocked. |
Dave Richard, Laval University |
| P. falciparum 3D7 | Gametocyte | !!
Not tested |
PMID: 29582546 (Conditional)
Apical complex and IMC biogenesis is disrupted. Cytokinesis blocked. |
Dave Richard, Laval University |
| P. falciparum 3D7 | Ookinete | !!
Not tested |
PMID: 29582546 (Conditional)
Apical complex and IMC biogenesis is disrupted. Cytokinesis blocked. |
Dave Richard, Laval University |
| P. falciparum 3D7 | Oocyst | !!
Not tested |
PMID: 29582546 (Conditional)
Apical complex and IMC biogenesis is disrupted. Cytokinesis blocked. |
Dave Richard, Laval University |
| P. falciparum 3D7 | Sporozoite | !!
Not tested |
PMID: 29582546 (Conditional)
Apical complex and IMC biogenesis is disrupted. Cytokinesis blocked. |
Dave Richard, Laval University |
| P. falciparum 3D7 | Liver | !!
Not tested |
PMID: 29582546 (Conditional)
Apical complex and IMC biogenesis is disrupted. Cytokinesis blocked. |
Dave Richard, Laval University |
Imaging data (from Malaria Metabolic Pathways)
The putative protein sorting receptor PfSortilin localizes to the P. falciparum Golgi apparatus. Co-localization of PfSortilin-HA and ERD2 in aldehyde-fixed clone C9 parasites. T, trophozoite; Sz, schizont. Scale bar, 2 mm. In trophozoite- and schizont-stage parasites, PfSortilin-HA localized to puncta that were also recognized by antibodies to the Golgi marker ERD2 (Fig. 4C). In ring-stage parasites, PfSortilin-HA could not be detected above non-specific background, even though the Golgi apparatus was present as determined by ERD2 immunolocalization.Krai P, Dalal S, Klemba M. Evidence for a Golgi-to-Endosome Protein Sorting Pathway in Plasmodium falciparum. PLoS One. 2014 9(2):e89771. PMID:
See original on MMPMore information
| PlasmoDB | PF3D7_1451800 |
| GeneDB | PF3D7_1451800 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | PF14_0493 |
| Orthologs | PBANKA_1315500 , PCHAS_1318800 , PKNH_1230300 , PVP01_1255200 , PVX_117890 , PY17X_1319300 |
| Google Scholar | Search for all mentions of this gene |